Dr. Nitish Mandal

Consultant Pain Physician

Dr. Nitish Mandal

What is prolotherapy, and how is it different from PRP?

Prolotherapy is a roughly 10-minute clinic injection of a glucose solution around injured tissue. PRP uses concentrated platelets from your own blood.

What is prolotherapy, and how is it different from PRP?

Prolotherapy is a roughly 10-minute clinic injection of local anaesthetic and a glucose solution around injured ligament or tendon tissue. PRP uses concentrated platelets from your own blood instead.

This article is from Dr. Nitish Mandal, Consultant Pain Physician in Bangalore, with clinics in Koramangala and J.P. Nagar. Reviewed by Dr. Nitish Mandal, MBBS, MD, FIPM, TIPM (Nashville).

Published 2025-06-01 · Updated 2026-09-22

What is prolotherapy?

Prolotherapy, or proliferation therapy, injects a natural stimulant into damaged tissue to promote healing. At this clinic that means local anaesthetic and a glucose solution around injured tissues. The procedure takes around 10 minutes.

Who it is for

Joint pain, ligament and tendon injuries, arthritis, back pain, knee pain, sports injuries, and neck pain. It is a clinic visit, not an admission.

How it differs from PRP

PRP uses concentrated platelets from your blood. Prolotherapy uses a glucose solution as the stimulant. Which one fits is decided after examination. Full details are on the prolotherapy and PRP pages.

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I have tried tablets and physiotherapy. What is different here?

Find the source of the pain, then treat that source with a clinic injection, block, or infusion. You are typically able to go home the same day.

Where are the clinics, and do I need an appointment?

Koramangala and J.P. Nagar. Prior appointment is preferred. You can book from this website.

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